Extended Release Felodipine Self-Nanoemulsifying System
نویسندگان
چکیده
منابع مشابه
Combined enalapril and felodipine extended release (ER) for systemic hypertension. Enalapril-Felodipine ER Factorial Study Group.
This multicenter, placebo-controlled, double-blind trial of factorial design evaluated the safety and efficacy of combination treatment with the angiotensin-converting enzyme inhibitor, enalapril, and the vascular selective calcium antagonist felodipine extended release (ER) in patients with essential hypertension. After a 4-week, single-blind placebo baseline period, 707 patients with sitting ...
متن کاملA factorial study of combination hypertension treatment with metoprolol succinate extended release and felodipine extended release results of the Metoprolol Succinate-Felodipine Antihypertension Combination Trial (M-FACT).
BACKGROUND Many hypertensive patients require combination therapy to achieve target blood pressure (BP). beta-Blockers and dihydropyridine calcium channel blockers are effective as monotherapy in hypertensive patients and have complementary mechanisms for lowering BP. METHODS This multicenter, randomized, placebo-controlled, unbalanced factorial study included a 4- to 5-week single-blind plac...
متن کاملPharmacokinetics and drug-drug interaction between enalapril, enalaprilat and felodipine extended release (ER) in healthy subjects
Since angiotensin-converting enzyme (ACE) inhibitors and calcium antagonists have complimentary mechanisms of action, enalapril, an ACE inhibitor, is used in combination with felodipine, a vascular selective dihydropyridine calcium antagonist, for the treatment of hypertension. The present study was designed to investigate the possible drug-drug interaction between these two agents in Chinese h...
متن کاملA crossover comparison of extended release felodipine with prolonged action nifedipine in hypertension.
In a crossover design, control of blood pressure by extended release felodipine was compared with control by prolonged action nifedipine in 21 children with renal hypertension. Compliance with once daily felodipine was higher than with nifedipine, at 95.6 (SEM 2.7)% v 78.9 (6.0)% (p = 0.02). Mean diastolic blood pressure was lower during the day with felodipine than with nifedipine, at 77.6 (2....
متن کاملIntroducing Self-Nanoemulsifying Drug Delivery System to Increase the Bioavailability of Oral Medications
Due to low cost, ease of administration, and lack need for trained personnel, the oral route is the most convenient and accessible way to design different medicines that could be simply consumed by patients. Regardless of the great benefits of this route, the main challenge in the bioavailability of oral medications is gastrointestinal instability. Nanotechnology is used to improve the solubili...
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ژورنال
عنوان ژورنال: AAPS PharmSciTech
سال: 2009
ISSN: 1530-9932
DOI: 10.1208/s12249-009-9235-0